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& Murakami, H

While the general principles of N-terminal acetylation and C-terminal amidation are well established in peptide chemistry, their specific effects on the AEDG sequences biological activity, pharmacokinetics in research models, and pathway engagement have not been formally evaluated in peer-reviewed literature (8)

Lastly, it is worth highlighting the development of trials based on innovative therapies developed within the region, which are on par with those conducted in high-income countries, such as dendritic cell-based vaccines used as neoadjuvant treatment, demonstrating the regions potential to develop therapies tailored to its population (190, 191)

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